DuoESI Source
The DuoESI source is powered by our award-winning multispray M3 emitter and breakthrough monolithic MEA chip, to significantly enhance ionization efficiency and achieve high sensitivity, throughput, and robustness for multiomics analysis.
Its swappable microflow and nanoflow modules deliver two ion sources (nano/micro) in one, reducing sample preparation and SOPs. It is compatible with mass spectrometers from five of the world’s leading mass spec vendors.
The DuoESI source is powered by our award-winning multispray M3 emitter and breakthrough monolithic MEA chip, to significantly enhance ionization efficiency and achieve high sensitivity, throughput, and robustness for multiomics analysis.
Its swappable microflow and nanoflow modules deliver two ion sources (nano/micro) in one, reducing sample preparation and SOPs. It is compatible with mass spectrometers from five of the world’s leading mass spec vendors.
Enhanced Workflow
Built for Superior Microflow and Nanoflow LC-MS
Sensitivity
5 - 50x
more sensitive compared to conventional methods.
Robustness
CV ≤ 5%
from 300 plasma injections.
Throughput
< 1 min.
per sample for direct infusion ESI. More than 60 samples per hour.
Product Configurations
Compatible with Agilent, Bruker, Shimadzu, and Thermo Fisher Mass Spectrometers
IS-A01D
for Agilent MS
Compatible with: 6500 Series Q-TOF, 6400 Series QQQ, 6200 Series TOF, and all other Agilent MS
IS-B01D
for Bruker MS
Compatible with: timsTOF series (timsTOF Pro, timsTOF Pro2, timsTOF SCP, timsTOF flex), Compact, impact II, and maxis II QTOF MS, maXisTOF flex MALDI-2 MS (ESI side), solariX and scimaX MRMS; amazon Ion Trap MS
IS-S01D
for Shimadzu Mass Spectrometers
Compatible with: LCMS-9030, LCMS-9050, LCMS-8045, LCMS-8050, LCMS-8060, LCMS-8060NX, and other Shimadzu LCMS
IS-T01D
for Thermo Fisher MS (New Generation)
Compatible with: Orbitrap Exploris (120, 240, 480), Orbitrap Tribrid Series (Fusion, Lumos, ID-X, Eclipse, Ascend), TSQ Series II (Endura, Quantiva, Altis, Quantis, Fortis)
IS-T02D
for Thermo Fisher MS (Legacy)
Compatible with: Q Exactive Series (QE Focus, QE, QE Plus, QE HF, QE HFX, QE UHMR), Exactive Series (Exactive Plus, Exactive Plus EMR), Orbitrap Elite LTQ Series (LTQ XL, LTQ Orbitrap XL, Velos Pro), LCQ Fleet TSQ Series (Quantum, Vantage)
Product Details
Features
- The first interchangeable microflow and nanoflow ion source by a simple swap
- Compatible with all mass spectrometers from Thermo, Bruker, Agilent, and Shimadzu
- Plug-and-play platform for nanoflow and microflow MEA chips
- Plug-and-play platform for M3 emitters
- Receive two ion sources for the price of one
Specifications
Parameter | Specifications |
---|---|
Ionization Mode | Atmospheric pressure electrospray ionization (ESI), both positive and negative mode. |
ESI Probe | Newomics M3 Emitter (refer to M3 Emitter and MEA Chip specification) |
Open or Closed System | Semi-closed source |
Flow Rate | Nano (20 – 1000 nL/min), for nanoMEA chips |
Spray Angle | Fixed angle of 25° for M3 emitters |
Capillary Voltage | 0 – 6 kV |
Spray Current | 0 – 10 µA, max. 40µA |
Sheath Gas Flow Setting | 0 – 30 (arbitrary units) |
N2 Nebulizer Gas Flow Setting | 0 – 60 psi |
Auxiliary Gas Flow Setting | 0 – 20 (arbitrary units, optional) |
Translational Stage | Linear XY-axis manual stage, ±5 mm travel distance, 30 µm travel accuracy |
Camera | 1.3M pixels, 20x ̶ 90x magnification rate, color CMOS sensor, up to 30 fps frame rate |
Light Source | Cool white (9000K) 5 mm round LED light, luminous intensity 46400 mcd |
Connection | Face seal, finger-tight 10-32 threaded fittings including Thermo nanoViper, IDEX MarvelX and MarvelXACT, Waters ZenFit, Phenomenex SecurityLink, VICI Cheminert C360IZR1, and nanoConnect |
Unit Dimension | Width: 25 cm (9.8 in.) |
Unit Weight | 3 kg (6.6 lbs) |
Model | Specifications |
---|---|
Catalog # IS-A01D | DuoESI Source for Agilent Mass Spectrometers: |
Catalog # IS-B01D | DuoESI Source for Bruker Mass Spectrometers: |
Catalog # IS-S01D | DuoESI Source for Shimadzu Mass Spectrometers: |
Catalog # IS-T01D | DuoESI Source for Thermo Fisher New Generation Mass Spectrometers: |
Catalog # IS-T02D | DuoESI Source for Thermo Fisher Legacy Mass Spectrometers: |
Literature
To request a DuoESI user guide, please contact us. Be sure to specify the catalog number.